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Stem cells. New name, same importance.
An idea whose time came a long time ago.
How are embryonic stem cells derived and
cultured? See a graphics slide show from University of Wisconsin: news.wisc.edu/thisweek/Research/Bio/Y98/frames.msql
A common question from the Embryonic
stem cell fact sheet
"If a cluster of these (stem) cells was
transferred to a woman, could a pregnancy result? No. These cells are not
the equivalent of an intact embryo. If a cluster of these cells was transferred
to a uterus, they would fail to implant, and would fail to develop into a
fetus."
news.wisc.edu/thisweek/Research/Bio/Y98/facts.html
Stem cells. Now that's a really complex subject
isn't it? Well no, not technologically --and yes, if you want to get obtusely
technical about scientific definitions. A sense of urgency has caused some new
arrivals to venture into areas which for them had heretofore remained uncharted
and unvisited, science and scientific methodology. Led by individuals with
dubious intentions at best, the activities of these new arrivals into the field
of science might be viewed as comical, somewhat like bulls in a china closet,
were it not for the damage left in their wake. Millions of otherwise
scientifically illiterate rightists pride themselves on being able to formulate
definitions which ostensibly have oodles and gobs of significance, if and only
if one accepts many other of their precepts, misconceptions, preconceptions, and prevarications
a priori.
 Georgius, "It's not scientific," W. Rush
The technological part needn't be all that
difficult. And that's been well known for more than two decades. We'd have
solved the technological bottlenecks years ago but for a lack of a little
cooperation from the Whitehouse. Just ask Ronald. Or try to ask him. He doesn't
say much these days. He's the one that first blocked stem cells a long time
ago. Navigator George or good old Bill could have corrected course. But they
didn't. Biomedical wizards have had to start doing much more difficult things
to get around the roadblock imposed by those silly folks with their precious
eschatalogical fantasies.
Example one, vascular cell precursors have been
injected into patients. The procedure does require modification of the cell
characteristics. The cells proliferated to the extent that selected areas of
the patient's bodies have successfully been revascularized. Esentialy a new, or
at least reconditioned, body part. That's a neat trick. Example two, previously
differentiated muscle cells are being injected into people's hearts. After
modification these cells have redifferentiated and changed to assume the
function if not the exact form of cardiac muscle cells. That's a really neat
trick. One cell type becomes another cell type. The new cells proliferate
within the heart and you have healthy heart tissue. Again a new, or at least
reconditioned, body part
Scientists are performing feats of wizardry
much more difficult than grabbing a few islet cells or pineal cells and
injecting them into a patient. A simple two step process, collect and inject.
Very simple technically. It could be put into practice lickity split. But
Ronald just said, "No." So we have to play Simon Says and jump through
extra hoops.
The road to the future leads straight through
Stem Cell City.
Let's make it real simple. Everybody, including
the eschatological fantasists, knows very well that the direct road to the
future passes smack dab through the middle of Stem Cell City. They know that
there are many more duckies in a line after the easiest first two duckies are
plinked off. Pineal cells and islet cells are just the easy first of many
successes waiting to happen after the flag drops and the horses bolt out of the
starting gates.
"Breaker, breaker 19, Do you copy? Come back!
Yeah? There's a roadblock up ahead. There's about a hundred cherry tops up
ahead in Stem Cell City, come back! Do you copy?"
You listen to the news sometimes, dont' you?
Haven't you ever wondered why you always hear Alheimer's and Diabetes together
with stem cells? Hello? Can you hear me? What's the heck's the matter? Have you
got Alzheimer's or Ojiisan no Mimi, or what? Say! Helloo?

Helloo? Why do you always seem to hear stem
cells, Alzheimer's and Diabetes in the same news blurb together?
Etiology. A simple A causes B type of
etiology.
What if there were a disease which had a very
simple and well defined etiology? What if that disease were due to a lack of
one single chemical compound? For example beri-beri., a disease of the
periphral nerves caused by deficiency of vitamin B1, characterized by pain in
and paralysis of the extremities, and a severe emaciation or swelling of the
body. Well, would be a no-brainer, wouldn't it? You would begin immediately to
count witches on pin heads while singing How Great Thou Art.
Prophylactic chanting of Hare Krishna would be optional. You would make
darn sure the patient gets no vitamin B1. If the patient's condition were to
improve who could say it wasn't an act of God?
What if there were one and sometimes two items
lacking as is the case with rickets? That's a disease of childhood
characterized by a softening of the bones and often resulting in deformities.
Would you make sure the patient got lots of vitamin D and calcium? Heck no. How
could that be deemed an act of God? How would that strengthen blind faith?
What if for one reason or another a patient
needs blood cells from another individual? Predictably, Americans choose to act
in a consistently inconsistent manner under these circumstances. Anybody with a
modicum of sense allows a technician to take a blood sample for a type and
cross. Everybody else, i.e., religious cultists can act like foolish
idiots. They can legally refuse the type and cross for themselves and for their
children. And they do. In which case you hear some singing How Great Thou
Art and watch someone die. In fairness, sometimes they do get lucky and
survive.When that happens who can say it's not an act of God? Does it make us
want to convert to religious cultism? Nope.


Image adapted from Stem Cell Primer, NIH, nih.gov/news/stemcell/primer.htm
What if the transfusion were autologous?. This
type of transfusion involves the collection of one kind of microanatomical body
part, blood cells, for later use for example for surgery. Autologous
transfusions are accepted by most. If the procedure involves collection and
reintroduction of red blood cells, most but not all, Americans give
their consent. Still, fanaticists with a religion-based aversion to technology
including biotechnology, who won't even watch television or use a light bulb,
will not allow this beneficial re-use of their own red blood cells. Red blood
cells are distantly removed from sacrosanct germinal tissue both
developmentally and chronologically. After differentiation red blood cells must
age to the point that they lose their nucleus and its nuclear material before
they assume their physiological function of carrying carbon dioxide and oxygen.
They have differentiated from pluripotent stem cells in bones which have
themselves differentiated from totipotent stem cells in earlier development.
White blood cells have nuclei. They are also spatially and developmentally
closer their stem cell precursors. As a consequence, consideration of white
blood cell transfusion, autologous or otherwise, automatically raises eyebrows
and prompts many to reach for their magnifying glasses. A consideration of
white blood cell transfusions performed so as to avoid fatal immunogenic
reaction is the cue which causes those magnifying glasses to be focused not on
patients but rather on pinheads.

 Insulin
What if a lacking compound is endogenous? What
if there's a well understood disease condition in which one cell type hidden
way down deep in the far flung Isles of Langerhans were either absent or out to
lunch? Diabetes. Insulin, a polypeptide 754 amino acid units in length would be
lacking. In this case Americans find it permissible to refrain from counting
witches on pinheads so long as the source of the necessary protein is
exogenous. At the suggestion that islet cells be placed inside the patient's
body to provide the insulin they go right back to counting witches on pinheads,
particularly when the islet cells used are ones which won't cause immunogenic
rejection. They form circles, hold each other's hands and start singing How
Great Thou Art. again.
What is the connection between Alzheimer's and
pineal cells? Healthy functioning pineal cells equals no Alzheimer's. Lack of
healthy functioning pineal cells equals Alzheimer's. Who put holding hands and
singing How Great Thou Art into the equation? Collect, inject, no
Alzheimer's. Ditto for other disease conditions. Which word(s) can't you
comprehend?


Where the heck is Paul Harvey when you really
need him? Surely somebody might want to know the rest of the story, wouldn't
you think? Ronald's condition with Alzheimer's was virtually self inflicted.
Don't you think that would be a supermarket check out line tabloid scoop of the
day? Scientists had expected a triumph over that one disease in particular,
Alzheimer's by using stem cells, many years ago. It was so easy, so simple, so
possible, so near, so logical. But Ronald just said, "No." If people ever got a
clear explanation from the media about what a clear cut solution scientists
have long known stem cells to be, the result would be a flip-flop in public
sentiment. It wouldn't take much. Some simple copy revisions. Just change ,
"scientists think," to, "scientists know," in a few places. Change, "might be,"
and, "may be," to, "is," in a few other places. You know, stuff like that.
After all there's nothing really wrong with telling it like the vast majority
of scientists who know all the ifs, ands, and buts know that it is. In
fact that would make a great many at the National Institutes of Health very
happy and satisfied.
BTW there is a very good Stem Cell Primer on
the NIH website at nih.gov/news/stemcell/primer.htm.
Probably you'd better hurry to view it, though. Georgius will probably make
them take it down if he hasn't done so already.
The desire to be healthy is great. The desire
to live is greater. The desire to both live and be healthy is greatest. The
desire to be politically correct about abstract biological definitions is
ultimately less than these two desires. The will to count witches on pin heads
will fade. The desire to split hairs and get really technical about right
wing-serving politically correct biological definitions will disappear
eventually, as people realize what the choices are.

Collect, inject. Stem cells are the
simple and straightforward solution which could essentially be put into effect
immediately. Lightning strikes, ships sink, tornadoes and hurricanes are nasty.
But you don't think you'll ever get hurt in a car accident? You don't think
your plane will ever crash? You don't think you'll develop diabetes? You don't
think you'll get one of the multiple other diseases for which stem cells are
the simple and straightforward solution? You better hope you don't. If your
luck is so constant why haven't you done the Rain Man thing in Vegas?
Ronald made the same mistake. He's in pretty sad shape now because of the
choices he made for himself-- and for you. How can you feel sorry for a guy who
refused treatment for himself and for everybody else at the same time? Do all
Americans wish to play the role of religious cultists, refusing treatment
everybody knows will work? Ronald trotted out the same old familiar cliches.
Said he was concerned about the unborn. Heck there are thousands of
unborn embryos in clinics everywhere. Shall we bring them all to term? If
you're one of those religious hair splitters for whom counting exactly how many
witches can dance on the head of a pin has not lost its lustre and appeal,
you'll probably want to ignore the fact that with genomic wizardry every cell,
whether it divides normally by mitosis or meiosis can be the start of a
complete organism. And your precious politically correct definitions will have
taken wings and flown right out the window. Would that make any difference to
you? Are you really motivated by a desire to be scientifically correct or by a
desire to be politically correct from a rightist's point of view?

And just what exactly was it that motivated
Ronald? Was it moral high ground? Was it noblesse oblige? Was it altruism?
Nope. He just didn't think he himself would develop Alzheimer's. Boy, was he
wrong.

All because he and his largest voting
constituency value some precious eschatalogical fantasies upon which they place
more value than they reserve for you. It seems like people for whom reason has
value live on a nunatak, completely surrounded by a glacier of that old-time
religious thinking. Or maybe isolated eremophytes living in an intellectually
barren desert. Will the next decade or the new millenium bring relief? As for
the latter, yes, certainly, it's inevitable. However, humanity will likely
hiccup or experience induced vomitting along the way. As for the former the
strategy seems to be to use any and every excuse to stall for time and hope the
future can be roadblocked or diverted for as long as necessary for reality and
theology to make a better semblance of being in sync.
OR..
Georgius is showing signs that he will continue
the absurdity of his predecessors. Well maybe he just wants to give folks
something to chirp about. Chirping is after all, an American tradition. We do
like to have something about which to chirp. Looks like he's not going to let
us down. How can you tell? Well, just for starters the NIH cancelled the
conference at which they wanted to announce research grant awards for stem cell
research this summer. Time will show that that was a pretty good omen, the
predictive value of which will have been better than reading tea leaves or
tarot cards.
What do you suppose is taking Georgius so long?
Here we have a slam-dunk, cut-and-dried, plain-and-simple, no-brainer. Georgius
reimposed the gag rule on day one. But he's been thinking about this piece of
executive legislation for six months. To which unbiased source is he turning
for support?
Georgius is huddling with the big Kahuna, of course.
Wise choice. And convenient. Who said Georgius didn't like Catholics? Can you
say instant legitimacy? It's kind of like instant ramen. But instead of adding
hot water and stirring... He's taking his royal time to prepare this particular
proclamation. Georgius is using his time well. He has to prepare well to sell
us his bill of goods. Georgius won't tell us for yet another two months that
his American government is not going to help us have the cures. When he does
everybody will no doubt welcome the news along with a check for $300. Until
then if one must chirp, it must necessarily be hypothetical chirping.
We enjoyed watching left wing idiots lobbing
petrol bombs (lit by government agents) in Genoa as much as anybody who watched
it. The irony. The intrigue. It's as good as any Shakespeare play.
Georgius performed outstandingly on his first
European tour. He trained G8 leaders to be good-ol' boys. He's got them winking
slyly and slapping each other on the back. There were plenty pathetically
misguided BOBOs just outside acting like pathetically misguided morons. You
know the routine; breaking windows, burning cars. In general just trashing the
heck out of Genoa while Georgius was inside conducting his training session.
You gotta love it. Say, Georgius, what's the name of the Spanish president? Who
cares when you're having this much fun, right?

If you're gonna fib, it may as well be a big
one. Georgius quieted all the ruckus about global warming with one outrageously
preposterous sentence, "It's not scientific." You can be sure this law school
should-have-been is capable of more astonishing things. We fully expect
Georgius to be a Good Ole Boy. After he makes his big stem cell decree we'll still
have plenty about which to chirp.
Chirp chirp.
Chirp chirp chirp.
 BushReport from Day One
 home.attbi.com/~wizardofwhimsy/
  Click bar to see how it turned out on Stem Finale Page.
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